Multiplayer will be making its return in Mass Effect Andromeda, according to Game Informer (via NeoGAF)- and it will be a more refined form of the multiplayer in Mass Effect 3. The game will, like so many other multiplayer games, have a card based economy, with players earning XP and credits. It will also have microtransactions, though Bioware insist that no real world money is required, and players can play through the multiplayer simply by earning credits in game.
Unlike Mass Effect 3, the multiplayer will not influence the ending of the single player game, though Bioware do admit that playing multiplayer can have advantages for the single player game. Bioware are also adding a new Prestige mechanic- with several types of characters, you can earn Prestige XP in addition to regular XP. Earning enough Prestige XP extends the benefits that character enjoys to other characters too.
Mass Effect Andromeda will launch on PS4, Xbox One, and PC.
Source: Rheena.com